Voythos
The precision medicine engine for vascular disease.
We’re a physician-founded startup building precision tools for vascular surgeons.
AortaNavigator
Predictive intelligence for AAA, TBAD, and TAA. Surveillance and screening at scale.
IN DEV
Pythia
A frontier multimodal model for the entire aorta. Pursuing FDA clearance.
Trained on 700,000+ longitudinal patient records. Backed by Mayo Clinic and Northwestern Medicine.
Research
Our models are developed and reviewed with academic vascular surgeons, and the results are presented at the meetings they attend.
Rapid-fire paper
October 2026
Development of a Risk Prevention Model for Intervention in Acute Type B Aortic Dissection
New England Society for Vascular Surgery, 53rd Annual Meeting
Doulamis I, Overtchouk P, Fernandes L, Khan S, Graves J, Lipsitz E, Makoid J, Indes J
With Lahey Hospital & Medical Center · Montefiore Medical Center · UMass Chan Medical School
Meeting program
E-poster
September 2026
Machine Learning Prediction of Renal Malperfusion After Acute Type B Aortic Dissection
Midwestern Vascular Surgical Society, 2026 Annual Meeting
Khan S, Overtchouk P, Makoid J, Graves J, Milner R
With The University of Chicago Medicine
View poster
All research
Pipeline
AortaNavigator
AAA, TBAD, TAA surveillance and care gaps
Available today for health system pilots.
Development
Retrospective validation
Health system pilots
Current
Deployment
Pythia for AAA
Abdominal aortic aneurysm
First FDA submission.
Model development
Retrospective validation
FDA Pre-Submission
Multi-site validation
Current
510(k) submission
Pythia for TBAD
Type B aortic dissection
Follows AAA as a second submission.
Model development
Retrospective validation
Current
FDA Pre-Submission
Multi-site validation
510(k) submission
Pythia is in development and has not been cleared or approved by the FDA. It is not available for clinical use.
We are a team with one goal: to improve patient care with emerging technologies grounded in clinical expertise.
Join our team
Leadership
Sophia Khan
Sophia Khan, MD
Co-Founder and CMO
Vascular Surgeon, UPMC. Built the oncologic vascular surgery program at UTHealth Houston.
Joe Makoid
Joe Makoid
Co-Founder and CEO
15 years in medtech, including robotics and digital surgery at Johnson & Johnson. MBA, Rice University.
Pavel Overtchouk, MD
Pavel Overtchouk, MD
Co-Founder and Head of Science
Interventional cardiologist turned AI engineer. Early author on AI in interventional cardiology.
Jordan Graves
Jordan Graves
CTO
Prev. Medical AI/ML Development
Clinical Advisors
Gustavo Oderich, MD
Gustavo Oderich, MD
Chief, Division of Vascular Surgery and Endovascular Therapy, Baylor College of Medicine
Ross Milner, MD
Ross Milner, MD
Chief, Section of Vascular Surgery and Endovascular Therapy, The University of Chicago Medicine
Partners
Research collaborators
The University of Chicago MedicineMontefiore Medical CenterLahey Hospital & Medical Center
Data partners
Mayo Clinic PlatformNorthwestern Medicine
Supported by
Forum VenturesTechstarsLifeXScience Center
Recognition
2026
Startup Battlefield 200
TechCrunch Disrupt
2027 cohort
Enrico Ascher Vascular Innovation Institute
SVS Foundation
2026
Radar Forum presenting company
MedTech Innovator
2025
Healthcare Accelerator
Techstars and Northwestern Medicine
2024
Platform_Accelerate
Mayo Clinic Platform
2024
Top 10 most promising life science companies
Texas Life Science Forum
2024
First place
LifeX Accelerator
News & Insights
Voythos selected for the SVS Foundation Enrico Ascher Vascular Innovation Institute
October 2026
Read more
Voythos research presented at the 2026 NESVS Annual Meeting
October 2026
Read more
Voythos selected for TechCrunch Startup Battlefield 200
October 2026
Read more
View all news